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Cannabis-Induced Depersonalization-Derealization Disorder: Unveiling the Complex Relationship


Cannabis use has long been associated with various psychiatric sequelae, including depersonalization-derealization disorder (DDD). This condition is characterized by persistent or recurrent experiences of feeling detached from oneself or one's surroundings, leading to distress and functional impairment. While the link between cannabis use and psychotic disorders is well-documented, limited research has focused on the specific clinical characteristics and risk factors related to DDD precipitated by cannabis use. In this blog, we aim to shed light on the complex relationship between cannabis and DDD, exploring the phenomenon of cannabis-induced depersonalization and its long-term consequences.

Understanding Depersonalization:

Depersonalization is characterized by detachment from the body, a sense of separation from reality, fear of going crazy, visual distortions, distorted perception of time, and a numbed emotional response. It often co-occurs with other disorders, such as depression and anxiety, yet it remains

underdiagnosed despite its relative prevalence in the general population.

An Evolutionary Perspective:

From an evolutionary standpoint, depersonalization may be considered an adaptive response to extreme stress. Intense stress triggers a reflex that suppresses emotional responses, but if this reflex overcorrects, it can lead to feelings of numbness and detachment. While this perspective provides valuable insight, further research is needed to understand the evolutionary implications of depersonalization fully.

Cannabis and Mental Health:

While cannabis possesses therapeutic potential for certain conditions, it has also been associated with depersonalization, psychosis, and other mental illnesses in vulnerable individuals.

Acute cannabis use can induce depersonalization symptoms, but genetics and stressful life events play a more significant role in individuals who develop persistent depersonalization after cannabis use.

Studies have established that cannabis and other drugs can reliably induce depersonalization in a dose-dependent manner, particularly during acute intoxication. However, a significant number of individuals experience prolonged and persistent depersonalization even after a single or limited exposure to cannabis. These individuals often describe their chronic symptoms as identical to those experienced during the acute intoxication state. The triggering intoxication episode is frequently reported as a terrifying or life-threatening experience accompanied by a loss of control.

Psychological and Neurological Explanations: The development of prolonged depersonalization following cannabis use has been attributed to a combination of psychological and neurological factors. Some individuals

may use depersonalization as a defence mechanism after acute intoxication, suggesting intrapsychic factors contribute to its persistence. Additionally, psychological stress, distressing life events, and anticipatory anxiety have been associated with the onset and maintenance of depersonalization symptoms. Furthermore, similarities have been observed between drug-induced "flashbacks" and depersonalization, suggesting a shared mechanism.

Cannabis and Frontolimbic Inhibition:

Various factors can contribute to depersonalization, but cannabis use and its effects on the frontolimbic inhibitory mechanism are particularly intriguing. Cannabis interacts with cannabinoid receptors in the nervous system, influencing pain regulation pathways, motor activity, mood, and higher cognitive processes. Research suggests that cannabis can precipitate depersonalization in a dose-dependent manner and alter cerebral blood flow, especially in the frontolimbic region of the brain.

Genetics and Vulnerability:

Genetics also play a role in determining individual susceptibility to the adverse effects of cannabis. People with a genetic polymorphism affecting the catechol-O-methyl transferase (COMT) gene may be more sensitive to the psychotomimetic effects of cannabis. Impaired dopamine metabolism, linked to the development of psychosis and schizophrenia, can be influenced by this genetic variation.

Understanding Flashbacks and Depersonalization: Flashbacks are sudden re-experiences of previous drug-induced altered states of consciousness. Similarly, individuals with depersonalization disorder may experience sensory, perceptual, or emotional re-experiences of their initial

depersonalization episode. Factors such as distressing drug intoxication, physiological stress, fatigue, and individual susceptibility have been linked to the occurrence of flashbacks. The relationship between flashbacks and depersonalization supports the notion that depersonalization may be a type of flashback phenomenon.

Anxiety as a Mediating Factor: Anxiety appears to play a crucial role in the onset and maintenance of drug-induced depersonalization. The experience of a "bad trip" during cannabis use can trigger intense anxiety and feelings of loss of control, leading to depersonalization symptoms. Subsequent anticipatory anxiety, avoidance behaviours, and

sensory or cognitive cues associated with the initial experience can trigger flashback-like re-experiences, further amplifying the symptoms.

Implications for Treatment: Understanding drug-induced depersonalization as a potential post-traumatic condition can inform treatment approaches. Addressing the traumatic aspects of the "bad trip" experience and targeting anxiety management strategies may be beneficial. Cognitive-behavioural therapy, including exposure therapy and anxiety reduction techniques, has shown promise in the treatment of depersonalization disorder. Furthermore, identifying and addressing underlying psychological factors and promoting resilience can contribute to symptom reduction and recovery.


The relationship between cannabis use and depersonalization-derealization disorder is a complex and multifaceted topic. While cannabis has therapeutic potential, it can also be associated with adverse mental health effects in vulnerable individuals. Acute cannabis use can induce depersonalization symptoms, but genetics and stressful life events play a significant role in determining persistent depersonalization. Understanding the neurobiological mechanisms underlying cannabis-induced depersonalization and the genetic factors involved is crucial for improving our knowledge and addressing the impact of cannabis on mental health. Continued research in this area will contribute to the development of targeted interventions and support for individuals affected by cannabis-induced depersonalization and related conditions. By exploring the relationship between flashbacks, anxiety, and depersonalization, clinicians can develop targeted treatment strategies to alleviate symptoms and improve the lives of individuals affected by this perplexing condition.

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